Functionalised Anodised Aluminium Oxide as a Biocidal Agent.

In this article, we describe the antimicrobial properties of a new composite based on anodic aluminium oxide (AAO) membranes containing propyl-copper-phosphonate units arranged at a predetermined density inside the AAO channels. The samples were prepared with four concentrations of copper ions and tested as antimicrobial drug on four different strains of Escherichia coli (K12, R2, R3 and R4). For comparison, the same strains were tested with three types of antibiotics using the minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. Moreover, DNA was isolated from the analysed bacteria which was additionally digested with formamidopyrimidine-DNA glycosylase (Fpg) protein from the group of repair glycosases. These enzymes are markers of modified oxidised bases in nucleic acids produced during oxidative stress in cells. Preliminary cellular studies, MIC and MBC tests and digestion with Fpg protein after modification of bacterial DNA suggest that these compounds may have greater potential as antibacterial agents than antibiotics such as ciprofloxacin, bleomycin and cloxacillin. The described composites are highly specific for the analysed model Escherichia coli strains and may be used in the future as new substitutes for commonly used antibiotics in clinical and nosocomial infections in the progressing pandemic era. The results show much stronger antibacterial properties of the functionalised membranes on the action of bacterial membranes in comparison to the antibiotics in the Fpg digestion experiment. This is most likely due to the strong induction of oxidative stress in the cell through the breakdown of the analysed bacterial DNA. We have also observed that the intermolecular distances between the functional units play an important role for the antimicrobial properties of the used material. Hence, we utilised the idea of the 2D solvent to tailor them.

A Low-Dimensional Layout of Magnetic Units as Nano-Systems of Combinatorial Logic: Numerical Simulations.

Nanotechnology has opened numerous ways for physically realizing very sophisticated nanodevices that can be fabricated exclusively using molecular engineering methods. However, the synthesis procedures that lead to the production of nanodevices are usually complicated and time consuming. For this reason, the destination materials should be well designed. Therefore, numerical simulations can be invaluable. In this work, we present numerical simulations of the magnetic behaviour of magnetic units shaped into nanometric strips as a low dimensional layout that can be used as nano-systems of combinatorial logic. We showed that magnetic layouts that contain fewer than 16 magnetic units can take on a specific configuration as a response to the input magnetic field. Such configuration can be treated as an output binary word. The layouts that contained various numbers of magnetic units showed different switching characteristics (utterly different order of inverting of strips' magnetic moments), thus creating numerous combinations of the output binary words in response to the analog magnetic signal. The number of possible output binary words can be increased even more by adding parameters--the system's initial magnetic configuration. The physical realization of the model presented here can be used as a very simple and yet effective encryption device that is based on nanometric arrays of magnetic units rather than an integrated circuit. The same information, provided by the proposed system, can be utilized for the construction of a nano-sensor for measuring of magnetic field with the possibility of checking also the history of magnetization.

How to Control the Distribution of Anchored, Mn12-Stearate, Single-Molecule Magnets.

Controlling the distribution of the Mn 12 -stearate, single-molecule magnets (SMMs) anchored on a select surface is expected to be a new method for tuning its interactions, and an investigation on the magnetic properties of separated magnetic molecules is also lacking. The anchoring of the SMMs at the surface with an assumed statistic distance between each other is not an easy task; nevertheless, in this work, we show a synthesis which allows for this in detail. The immobilization of the Mn 12 -stearate was demonstrated with the use of FTO glasses and spherical silica as substrates. Based on differential pulse anodic stripping voltammetry (DPASV) and transmission electron microscopy (TEM) observations, we proved the efficiency of the method proposed. We observed continuous decreasing the number of bonds, and afterward, decreasing in the number of immobilized molecules with an increasing the number of spacer units used for separation of the magnetic particles.